解剖学和形态学
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细胞和组织工程学
临床神经病学
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牙科,口腔外科和医学
皮肤病学
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心理学,临床
abstract::The effect of retinoids on the induction of both epithelial and mesenchymal tumors of the rat kidney by a single dose of 40 mg/kg dimethylnitrosamine was tested using 13-cis-retinoic acid and the trimethylmethoxy phenyl analog of retinoic acid ethylamide. 13-cis-retinoic acid was administered for 3 weeks, 10 weeks, or...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.5.665
更新日期:1984-05-01 00:00:00
abstract::We investigated whether the addition of d-limonene to the diets of rats would modify the process of mammary tumor induction by 7,12-dimethylbenz[a]anthracene (DMBA). When diets containing 1000 or 10 000 p.p.m. d-limonene were fed to rats from one week before DMBA administration to the end of the experiment (27 weeks p...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.5.661
更新日期:1984-05-01 00:00:00
abstract::Styrene oxide was reacted with guanosine in fully aqueous conditions, and the products were purified by cation exchange chromatography and h.p.l.c. The products were characterized by u.v. and mass spectra, loss of tritium from the C-8 position and dissociation properties. About 90% of the total product was identified,...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.5.601
更新日期:1984-05-01 00:00:00
abstract::Carcinogen treatment of cultured mammalian cells prior to infection with u.v.-irradiated virus results in enhanced virus survival and mutagenesis suggesting the induction of SOS-type processes. In this paper, we report the development of a primary rat hepatocyte culture system to investigate cellular responses to DNA ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.4.495
更新日期:1984-04-01 00:00:00
abstract::Initiation with the carcinogen 7,12-dimethylbenz[a]anthracene followed by promotion with the hyperplasiogenic phorbol ester 12-O-tetradecanoylphorbol-13-acetate carried out on the dorsal skin of European hamsters (Cricetus cricetus L.) led to the formation of a broad spectrum of skin tumors in terms of a two-stage pri...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.4.521
更新日期:1984-04-01 00:00:00
abstract::Nitrosododecamethyleneimine (NDMI) was given to NZR/Gd rats by gavage in olive oil solution, confirming its hepatocarcinogenic activity. Twenty male and 20 female rats received 2.5 mg NDMI twice a week for 52 weeks; a further 10 male rats received 25.0 mg twice a week for 12 weeks. Two-thirds of the animals survived m...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.4.537
更新日期:1984-04-01 00:00:00
abstract::The promoting action of hexachlorocyclohexane (HCH) was evaluated in female Wistar rats by counting the gamma-glutamyltranspeptidase-positive foci which appeared in the liver after diethylnitrosamine (DENA) initiation. Liver tumor promotion by HCH was further confirmed in a long-term tumorigenicity study after DENA pr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.4.479
更新日期:1984-04-01 00:00:00
abstract::Formation and removal of hepatic DNA adducts was studied in male Sprague-Dawley rats following single injections of two hepatocarcinogens, N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) and a nonhepatocarcinogen, N-hydroxy-2-acetylaminophenanthrene (N-OH-AAP) at 0.5 h, 1.5 h...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.3.343
更新日期:1984-03-01 00:00:00
abstract::We investigated, in a cloned hamster tracheal epithelial cell line HTE-B, the effects of inhibitors of DNA topoisomerase, novobiocin and nalidixic acid; of DNA polymerase, 1-beta-arabinofuranosylcytosine (ara-C) and 2',3'-dideoxythymidine; of ribonucleotide reductase, hydroxyurea; and of poly(ADP-ribose)synthetase, 3-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.2.187
更新日期:1984-02-01 00:00:00
abstract::A single i.p. injection of 12-O-tetradecanoylphorbol-13-acetate (TPA) induced a transient increase in the levels of rat liver putrescine, spermidine and spermine. These polyamine concentrations continuously increased until 6 h, immediately following administration of the tumor promoter. Phenobarbital (PB) induced an i...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.2.225
更新日期:1984-02-01 00:00:00
abstract::We have examined both the initial nuclease sensitivity and subsequent nucleosome rearrangement of newly repaired regions of chromatin in human diploid fibroblasts treated with methyl methanesulfonate (MMS) and methylnitrosourea (MNU). We initially examined the effect of these two alkylating agents on DNA replicative s...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.2.245
更新日期:1984-02-01 00:00:00
abstract::The physiological state of pregnancy confers significant resistance to polycyclic aromatic hydrocarbon (PAH)-induced mammary tumorigenesis. We have tested the abilities of primary mammary cells from pregnant and virgin rats cultured on collagen-coated plates to metabolize PAHs and convert these carcinogens to mutageni...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.1.103
更新日期:1984-01-01 00:00:00
abstract::We have recently shown that a variety of human tumor cell lines are capable of preventing chloroethylnitrosourea (CNU)-induced DNA crosslinks, presumably by removing guanine O6-chloroethyl DNA monoadducts before crosslinks can form. Those cells capable of preventing crosslinking were of the Mer+ (Methylation repair) p...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.1.83
更新日期:1984-01-01 00:00:00
abstract::Comparative X-ray crystallographic structure analyses have been carried out on seven cyclopenta[a]phenanthrenes, namely 15,16-dihydocyclopenta[a]phenanthren-17-one and its 2-, 6- and 12-methyl homologues (non-carcinogens) and the 7-and 11-methyl and 1,11-methano derivatives (carcinogens). All-valence-electron molecula...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.12.1569
更新日期:1983-12-01 00:00:00
abstract::The inhibitory effects of three phenolic compounds (ferulic, chlorogenic and ellagic acids) on benzo[a]pyrene- and 7,12-dimethylbenz[a]anthracene-induced neoplasia have been investigated in mice. Ellagic acid was the most potent antagonist of tumorigenesis since this compound is active, by i.p. administration or added...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.12.1651
更新日期:1983-12-01 00:00:00
abstract::Previous studies had indicated that complete skin tumor promoters of the phorbol ester class induce epidermal transglutaminase and cornification in a subpopulation of cultured mouse epidermal basal cells in proportion to their promoting properties. This report describes the effect of promoting agents other than phorbo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.11.1413
更新日期:1983-11-01 00:00:00
abstract::Comparisons of aromatic amine activation were made by using intact cells or cell homogenates (S-9) from bovine bladder urothelium and liver. Since both liver and bladder are thought to contribute carcinogenic metabolites for bladder cancer initiation, comparisons of these two organs' relative ability to activate aroma...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.11.1401
更新日期:1983-11-01 00:00:00
abstract::A defect in DNA repair coupled to anomalous DNA synthesis after induction of certain radiogenic DNA damage is suspected to underlie the radiosensitivity of cells from patients with ataxia-telangiectasia (A-T). The response of cultured skin fibroblasts from A-T patients and A-T heterozygotes to six agents inducing vari...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.10.1317
更新日期:1983-10-01 00:00:00
abstract::Modulation of microsome mediated benzo[a]pyrene (BP) metabolism by oleic and linoleic acids was studied. Oleic and linoleic acids did not influence the apparent activity of aryl hydrocarbon hydroxylase or the relative ratios of BP-7,8-dihydrodiol to phenol metabolites on high performance liquid chromatography. The tot...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.10.1253
更新日期:1983-10-01 00:00:00
abstract::The development of a variety of odontogenic lesions was elicited by a single i.p. injection of N-nitroso-N-methylurea (NMU) at a dose of 150 mg/kg body weight. A total of 190 male Wistar/Furth rats were used in this study. The odontogenic lesions appeared macroscopically, mainly as supernumerary lower incisors, 88 +/-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.9.1085
更新日期:1983-09-01 00:00:00
abstract::The effect of a deoxycholic acid instillation on colonic epithelium was investigated and compared with the effect of an intervention scheme in which deoxycholic acid (DCA) treated mice received oral supplements of calcium lactate. The morphology of colonic tissue exposed to DCA was markedly affected when compared to t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.9.1205
更新日期:1983-09-01 00:00:00
abstract::The possible effect of oral 13 cis retinoic acid (13-cis-RA) on the carcinogenic process induced by 28 weekly s.c. injections of 1,2-dimethylhydrazine (DMH) in 34 Wistar rats was investigated. Using immunohistology, precancerous and cancerous stages were compared with the same stages induced by DMH without additional ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.9.1175
更新日期:1983-09-01 00:00:00
abstract::The levels of S-adenosylmethionine (AdoMet) and of S-adenosylhomocysteine (AdoHcy) as well as the ratio of AdoMet/AdoHcy were determined in the liver, lungs, testes and kidneys of weanling male rats fed a commercial chow diet or 5 different amino acid-defined diets for 1-5 weeks. The amino acid-defined diets used were...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.8.1051
更新日期:1983-08-01 00:00:00
abstract::Chloroethylnitrosoureas (CNU) are antitumor agents which produce DNA interstrand crosslinks. We have proposed that crosslinks are produced in DNA via monoadduct formation at the guanine-O6 position, followed by a delayed reaction with the opposite DNA strand. Human cells are known to differ in their capacity to repair...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.6.759
更新日期:1983-01-01 00:00:00
abstract::1,3-Dimethyl-3-phenyl-1-nitrosourea (DMPNU) shows no spontaneous decomposition in aqueous buffered solution (pH 7.0) at 37 degrees C over a measuring period of 10 days, but it is directly genotoxic in all assays applied. This compound induces base substitutions in Salmonella typhimurium (especially in the plasmid harb...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.4.409
更新日期:1983-01-01 00:00:00
abstract::Male ICR Swiss mice, weighing 16-20 g, were fed ad libitum either a fat-free diet or a diet containing 10% corn oil. After three weeks on these diets, the rates of benzo[a]pyrene (B[a]P) metabolite formation and metabolism to products which covalently bind with macromolecules were compared using hepatic nuclei and mic...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.1.9
更新日期:1983-01-01 00:00:00
abstract::Teleocidin, a new tumor promoter, increased incorporation of radioactive inorganic phosphate (32Pi) into phospholipids in HeLa cells. This effect was detected within 1 h on incubation of the cells in medium containing teleocidin. The half-maximum effective dose of teleocidin was approximately 10 ng/ml. The main effect...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.1.107
更新日期:1983-01-01 00:00:00
abstract::A method was devised to quantitate N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) induced crosslinking of the ionic complex between [methyl-3H]thymidine labeled pBR322 DNA and lysozyme. This involved chromatography of the modified complex on Sephadex CM 25 with a high salt buffer that dissociated the non-covalently bo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.5.501
更新日期:1983-01-01 00:00:00
abstract::Treatment of SV40-infected CV-1 cells with the ultimate carcinogen anti-benzo[a]pyrene diol epoxide (BPDE) at 1 X 10(-4) mg/ml or higher reduced the rate of viral DNA synthesis to an extent dependent on the BPDE concentration; similar reductions in cellular DNA synthesis were produced in infected and uninfected cells....
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.2.125
更新日期:1983-01-01 00:00:00
abstract::Groups of male and female IF strain mice were fed a diet containing either 0.5% or 1.0% paracetamol for up to 18 months. Among male mice fed the higher dose, the total liver cell tumour incidence was 87%, 21.7% developing hepatocellular carcinomas: both yields were statistically significant. The corresponding incidenc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.4.363-a
更新日期:1983-01-01 00:00:00
abstract::Adult rat hepatocytes in primary culture were used to study the effect of tryptophan pyrolysis products on the transcriptional process. Hepatocytes were treated with 1, 5 and 10 micrograms/ml of 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]-indole (Trp-P-1) or 3-amino-1-methyl-5H-pyrido-[4,3-b]-indole (Trp-P-2) for 2 and 4 h...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.4.481
更新日期:1983-01-01 00:00:00
abstract::Antibodies specific for u.v.-induced DNA damage were raised in rabbits, and used to study damage and repair of nuclear DNA in nude mouse and human skin in vivo by immuno-fluorescence and immunoperoxidase techniques. Purification of the antibodies by affinity chromatography strongly reduced unspecific background staini...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.6.745
更新日期:1983-01-01 00:00:00
abstract::The rat liver microsomal metabolism of 3-deutero-6-nitrobenzo(a)pyrene ([3-2H]6-NO2-BaP) was studied. The metabolites were separated by h.p.l.c. The 500 MHz 1H n.m.r. spectral analysis of the metabolites indicated that the 3-hydroxy-6-NO2-BaP and 6-NO2-BaP-3,9-hydroquinone each retained 33% of the deuterium label at t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.6.699
更新日期:1983-01-01 00:00:00
abstract::2-3H-Labelled 4-acetoxyaminoquinoline-1-oxide (Ac-4 HAQO), the ultimate carcinogen model of 4-nitroquinoline-1-oxide, was reacted in vitro with native and denatured DNA. We found that Ac-4 HAQO is 2- to 3-fold more reactive than diAc-4 HAQO, another ultimate carcinogen model of 4 NQO which was previously studied [Gali...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.3.249
更新日期:1983-01-01 00:00:00
abstract::Two mutagenic compounds have been isolated and purified from commercial beef extract. These two compounds have chemical, chromatographic, spectroscopic and biological behavior indistinguishable from those of the two known mutagens 2-amino-3-methyl-imidazo-[4,5-f]-quinoline and 2-amino-3,8-dimethyl-imidazo-[4,5-f]-quin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.7.863
更新日期:1983-01-01 00:00:00
abstract::The dysplastic nevus syndrome (DNS) is a preneoplastic melanocyte abnormality which occurs in families affected by hereditary cutaneous malignant melanoma (HCMM). A putative role of host-environmental interactions in the etiology of hereditary melanoma has been strengthened by the recent finding that fibroblasts deriv...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.7.911
更新日期:1983-01-01 00:00:00
abstract::Radioactive methylnitrosourea, epichlorohydrin, styrene oxide, and N-acetoxy-2-acetylaminofluorene were reacted with 14 different polyamino acids in vitro, to determine the relative reactivity of the functional groups in amino acids. All the carcinogens reacted preferentially with polycysteine and much less with polyh...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.1.1
更新日期:1983-01-01 00:00:00
abstract::The influence of the enzymatic inducer beta-naphthoflavone (BNF) and of the inhibitors alpha-naphthoflavone (ANF) and 2-diethylaminoethyl-2,2-diphenylvalerate HCl (SKF 525-A) on the frequency of sister chromatid exchanges (SCE) induced by cyclophosphamide (CPA) was studied in vivo in C57BL/6J male mice. Neither induce...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.1.83
更新日期:1983-01-01 00:00:00
abstract::Four inbred strains of mice (C3H/HeJ, C57BL/6J, AKR/J, and DBA/2J) were injected s.c. with 150 micrograms of dibenz[a,h]anthracene and followed for 9 months. Strains C3H/HeJ and C57BL/6J were most susceptible to dibenz[a,h]anthracene-induced carcinogenesis with 80% and 53% incidence of tumors, respectively. Strains AK...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.5.513
更新日期:1983-01-01 00:00:00
abstract::A number of drug-metabolizing systems were measured in hyperplastic noduli from the livers of rats receiving 2-acetyl-aminofluorene in their diet and compared with corresponding activities in control liver. The level of microsomal cytochrome P-450 is reduced 54% in the nodular tissue, while 5 activities catalyzed by t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.5.577
更新日期:1983-01-01 00:00:00